Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.
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Description | PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. |
Synonyms | PF5274857 HCl, PF 5274857, PF-5274857, PF-5274857 mesylate, PF-5274857 mseylate |
Molecular Weight | 533.06 |
Formula | C21H29ClN4O6S2 |
CAS No. | T28388 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PF-5274857 mseylate (1373615-35-0 free base) T28388 PF5274857 HCl PF 5274857 mseylate (1373615 35 0 free base) 1373615-35-0 PF5274857 mseylate (1373615350 free base) 1373615-35-0 free base PF 5274857 PF5274857 PF 5274857 Mesylate PF-5274857 PF-5274857 mesylate PF-5274857 Mesylate PF5274857 Mesylate PF-5274857 mseylate inhibitor inhibit