Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 88.00 | |
5 mg | 5 days | $ 148.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 178.00 |
Description | PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor. |
In vitro | PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current. This shows the major TTX-S conductance is carried through Nav1.7 channels in small-diameter mouse DRG neurons (n = 35)[1]. |
In vivo | PF-05198007 (1 or 10 mg/kg, orally) decreases the capsaicin flare response in WT. However, it not reduces Nav1.7Nav1.8Cre mice[1]. |
Molecular Weight | 533.91 |
Formula | C19H12ClF4N5O3S2 |
CAS No. | 1235406-19-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-05198007 1235406-19-5 Others PF 05198007 PF05198007 inhibitor inhibit