keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4), demonstrating specificity by not influencing PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 247.00 | |
25 mg | In stock | $ 418.00 | |
50 mg | In stock | $ 596.00 | |
100 mg | In stock | $ 863.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 235.00 |
Description | PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)), is a selective activator of the proteinase-activated receptor-4 (PAR-4), demonstrating specificity by not influencing PAR-1 or PAR-2, and its activity can be inhibited by a PAR-4 antagonist. |
In vivo | SCID mice demonstrate a markedly enhanced abdominal response to colorectal distension (CRD), with distension levels ranging from 0.04 to 0.1 mL amplifying the intensity of the EMG response from 384% to 132%, respectively, as compared to BALB/cBy controls (P<0.01; P<0.01; P<0.01; P<0.001). Activation of PAR-4 significantly mitigates this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1]. |
Synonyms | PAR-4-AP (TFA), AY-NH2 (TFA) |
Molecular Weight | 794.82 |
Formula | C36H49F3N8O9 |
CAS No. | 1228078-65-6 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (125.81 mM), Sonication is recommended.
DMSO: 250 mg/mL (314.54 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PAR-4 Agonist Peptide, amide TFA 1228078-65-6 GPCR/G Protein Protease-activated Receptor PAR-4-AP (TFA) Thrombin receptors PAR4 Agonist Peptide, amide TFA Protease Activated Receptor (PAR) inhibit PAR-4 Agonist Peptide, amide Inhibitor PAR-4-AP PAR 4 Agonist Peptide, amide TFA AY-NH2 AY-NH2 (TFA) inhibitor