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Org 25543

Name: Org 25543
Brand: TargetMol
SKU: T50082
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50082Cas No. 363628-88-0

Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.

Org 25543

🥰Excellent

Purity: 99.13%

Catalog No. T50082Cas No. 363628-88-0

Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.

Pack Size	Price	Availability
1 mg	$53	In Stock
5 mg	$123	In Stock
10 mg	$183	In Stock
25 mg	$305	In Stock
50 mg	$413	In Stock
100 mg	$580	In Stock
200 mg	$763	In Stock
1 mL x 10 mM (in DMSO)	$138	In Stock

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Batch Information

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Purity:99.13%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.

Chemical Properties

Molecular Weight	412.52
Formula	C₂₄H₃₂N₂O₄
Cas No.	363628-88-0
Smiles	O(CC1=CC=CC=C1)C2=C(OC)C=C(C(NCC3(N(C)C)CCCC3)=O)C=C2OC
Relative Density.	1.16 g/cm3 (Predicted)
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (133.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4241 mL	12.1206 mL	24.2412 mL	121.2062 mL
5 mM	0.4848 mL	2.4241 mL	4.8482 mL	24.2412 mL
10 mM	0.2424 mL	1.2121 mL	2.4241 mL	12.1206 mL
20 mM	0.1212 mL	0.6060 mL	1.2121 mL	6.0603 mL
50 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4241 mL
100 mM	0.0242 mL	0.1212 mL	0.2424 mL	1.2121 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc