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Omidenepag isopropyl

Catalog No. T16388   CAS 1187451-19-9

Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as intraocular pressure (IOP)-lowering drug.

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Omidenepag isopropyl Chemical Structure
Omidenepag isopropyl, CAS 1187451-19-9
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50 mg 8-10 weeks $ 789.00
100 mg 8-10 weeks $ 1,280.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as intraocular pressure (IOP)-lowering drug.
In vivo Omidenepag isopropyl is hydrolyzed in the eye to Omidenepag (OMD), an EP2 receptor agonist, with a significant ocular hypotensive effect in both ocular normotensive and hypertensive animal models[1]. Omidenepag isopropyl also displays significant and dose-dependent IOP-lowering effects at doses of 0.0001%, 0.001%, and 0.01% in ocular normotensive monkeys, with mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg at each tested concentration, respectively. Omidenepag isopropyl at 0.0001%, 0.001%, or 0.01%, Xalatan, or vehicle was topically administered to one eye in ocular normotensive monkeys. IOP changes after drug administration were compared to the predosing baseline value established on day 1.?The significant decreases in IOP for 0.001% and 0.01% OMDI at time 0 of day 7. In ocular hypertensive monkeys finds that Omidenepag isopropyl lowers IOP by increasing both trabecular outflow facility and uveoscleral outflow[2].
Molecular Weight 520.6
Formula C26H28N6O4S
CAS No. 1187451-19-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Kirihara T, et al. Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):145-153. 2. Fuwa M, et al. Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, on Aqueous Humor Dynamics in Laser-Induced Ocular Hypertensive Monkeys. J Ocul Pharmacol Ther. 2018 Sep;34(7):531-537.

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Keywords

Omidenepag isopropyl 1187451-19-9 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor inhibitor inhibit

 

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