This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Olprinone Hydrochloride
Catalog No. T5033L CAS
119615-63-3
Olprinone Hydrochloride, also known as Loprinone, is a phosphodiesterase (PDE) 3 potent inhibitor, exhibiting IC50 values of 150, 100, 0.35, and 14 μM for PDE1, PDE2, PDE3, and PDE4, respectively. It is utilized in heart failure research for its positive inotropic and vasodilative properties. It also exhibits anti-inflammatory activity [1] [2].
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Olprinone Hydrochloride, also known as Loprinone, is a phosphodiesterase (PDE) 3 potent inhibitor, exhibiting IC50 values of 150, 100, 0.35, and 14 μM for PDE1, PDE2, PDE3, and PDE4, respectively. It is utilized in heart failure research for its positive inotropic and vasodilative properties. It also exhibits anti-inflammatory activity [1] [2].
In vivo
Olprinone (Loprinone) Hydrochloride (0.2 mg/kg; i.p.) effectively mitigates inflammation and reduces myocardial damage in ischemia-reperfusion injury within male adult Wistar rats (250-300 g) designated as ischemia–reperfusion models. Administered intraperitoneally 15 minutes post-ischemia, it markedly lowers histologic signs of cardiac injury, diminishes levels of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), decreases expression of adhesion molecules such as Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, reduces nitrotyrosine formation, suppresses nuclear factor kappa-B (NF-κB) expression, curtails Poly (ADP-ribose) (PAR) formation, and lessens apoptosis, as evidenced by alterations in Bax, Bcl-2, Fas-L levels and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL) outcomes.
Molecular Weight
286.72
Formula
C14H11ClN4O
CAS No.
119615-63-3
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.