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Nicotinamide riboside tartrate

Catalog No. T40059 CAS 2415657-86-0

Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.

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Nicotinamide riboside tartrate Chemical Structure

Nicotinamide riboside tartrate, CAS 2415657-86-0

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Description	Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.
In vitro	Nicotinamide riboside tartrate at a concentration of 0.5 nM over 24 hours has been shown to lessen the acetylation levels of Ndufa9 and SOD2, as evidenced in HEK293T cells using Western Blot Analysis[1]. Furthermore, this compound significantly elevates both intracellular and mitochondrial NAD+ content in a range of cell lines (C2C12, Hepa1.6, and HEK293 cells) in a dose-dependent manner, with effective concentrations spanning from 1-1000 μM[1]. Additionally, it enhances NAD availability, thereby reactivating antiviral poly(ADP-ribose) polymerase (PARP) functions, which bolster innate immunity against coronaviruses (CoVs), implicated in the causation of COVID-19[3].
In vivo	Chronic supplementation of Nicotinamide riboside tartrate (p.o.; 400 mg/kg/day; for 16 weeks) resulted in an increase in both plasma and intracellular NAD+ levels, with the effects varying across different tissues. This study utilized 10-week-old C57Bl/6J mice (n=1) and administered the compound orally at a dosage of 400 mg/kg daily over a 16-week period, leading to a significant elevation in NAD+ content in a tissue-specific manner.

Molecular Weight	404.328
Formula	C15H20N2O11
CAS No.	2415657-86-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. 2. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. 3. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.

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Keywords

Nicotinamide riboside tartrate 2415657-86-0 Nicotinamide riboside Tartrate inhibitor inhibit

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