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Nicotinamide riboside malate

Catalog No. T40060 CAS 2415659-01-5

Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and provides protection against metabolic abnormalities induced by a high-fat diet. Additionally, Nicotinamide riboside malate mitigates cognitive decline in a genetically modified mouse model of Alzheimer's disease.

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Nicotinamide riboside malate Chemical Structure

Nicotinamide riboside malate, CAS 2415659-01-5

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Description	Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and provides protection against metabolic abnormalities induced by a high-fat diet. Additionally, Nicotinamide riboside malate mitigates cognitive decline in a genetically modified mouse model of Alzheimer's disease.
In vitro	Nicotinamide riboside malate, at a concentration of 0.5 nM for 24 hours, has been shown to decrease the acetylation levels of Ndufa9 and SOD2, as observed through Western Blot Analysis in HEK293T cells[1]. Furthermore, it enhances the cellular and mitochondrial levels of NAD+ in a dose-dependent manner across a range of concentrations from 1-1000 μM in C2C12, Hepa1.6, and HEK293 cells[1]. Notably, this compound has the ability to elevate NAD levels, thereby augmenting the functionality of antiviral poly(ADP-ribose) polymerases (PARP), which play a critical role in fortifying innate immune defenses against coronaviruses, including the strain responsible for COVID-19[3].
In vivo	Chronic supplementation with Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) elevates plasma and intracellular NAD+ levels in a tissue-specific manner[1]. This effect was observed in a study conducted on 10-week-old C57Bl/6J mice administered orally with a daily dosage of 400 mg/kg for a period of 16 weeks, leading to an increase in both plasma and intracellular NAD+ content, highlighting the compound's potential for targeted therapeutic applications.

Molecular Weight	388.329
Formula	C15H20N2O10
CAS No.	2415659-01-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. 2. Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8. 3. Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.

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Keywords

Nicotinamide riboside malate 2415659-01-5 Nicotinamide riboside Malate inhibitor inhibit

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