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NiCur

Catalog No. T60888

NiCur blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur is a potent and selective inhibitor of CBP histone acetyltransferase (HAT) with an IC 50 value of 0.35 μΜ. NiCur can be used to perform mechanistic studies without affecting target proteins expression [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NiCur, CAS N/A

Pack Size	Availability	Price/USD	Quantity
100 mg	10-14 weeks	$ 1,190.00
200 mg	10-14 weeks	$ 1,842.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

In U2OS cells, NiCur applied at concentrations of 0.5 to 1 μM significantly diminishes Dox-induced acetylation at lysine 382 on p53 (p53K382ac), phosphorylation at serine 15 on p53 (p53S15p), and overall p53 levels in a dose-dependent fashion. At a higher concentration of 1.5 μM, NiCur lowers acetylation at lysine 27 on histone H3 (H3K27ac) and restores cell proliferation in these cells. Moreover, in intestinal epithelial cells, NiCur suppresses Dox-induced activation of p53 without altering acetylation at serine 139 on histone H2A.X (H2A.X S139p). NiCur thus serves as a modulator of gene regulation by reprogramming the chromatin landscape, primarily by inhibiting CBP histone acetyltransferase (HAT) activity. Western Blot Analysis in U2OS cells corroborates these findings, showing a concentration-dependent reduction in p53K382ac, p53S15p, and p53 levels with NiCur treatment.

Molecular Weight	324.38
Formula	C22H16N2O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NiCur inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.