Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM).
Description | Neoseptin 3 is an agonist of Toll-like receptor 4/myeloid differentiation factor 2 (EC50: 18.5 μM). |
Targets&IC50 | mTLR4/MD-2:(EC50)18.5 μM |
In vitro | Neoseptin-3 causes TNFα production by macrophages in a concentration-dependent manner. TANK-binding kinase 1 (TBK1) and IRF3 phosphorylation also enhance in response to Neoseptin-3. Neoseptin-3 leads to phosphorylation of IκB kinases α (IKKα), IKKβ, p38, c-Jun N-terminal kinase (JNK), and ERK, and degradation of IκBα, consistent with activation of MAPK and canonical NF-κB signaling. . |
Molecular Weight | 474.59 |
Formula | C29H34N2O4 |
CAS No. | 1622863-21-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (210.71 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Neoseptin 3 1622863-21-1 Others inhibitor inhibit