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(E/Z)-Necrosulfonamide

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

Catalog No. T7129Cas No. 432531-71-0

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Purity:98%

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COA HNMR

(E/Z)-Necrosulfonamide

Catalog No. T7129Cas No. 432531-71-0

(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$50	In Stock
10 mg	$71	In Stock
25 mg	$120	In Stock
50 mg	$205	In Stock
100 mg	$308	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock

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Product Introduction

Bioactivity

Description	(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.
In vivo	Necrosulfonamide attenuates the spinal cord injury via necroptosis inhibition[1]
Animal Research	Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and other major organs. Necroptosis-related factors-RIP1, RIP3, and MLKL-were detected using Western blot. Detections on mitochondrial functions such as adenosine triphosphate generation and activities of superoxide dismutase and caspase-3 were also performed. Finally, ethologic performance was detected using a 21-point open-field locomotion test[1].

Chemical Properties

Molecular Weight	461.47
Formula	C₁₈H₁₅N₅O₆S₂
Cas No.	432531-71-0

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (54.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1670 mL	10.8349 mL	21.6699 mL	108.3494 mL
5 mM	0.4334 mL	2.1670 mL	4.3340 mL	21.6699 mL
10 mM	0.2167 mL	1.0835 mL	2.1670 mL	10.8349 mL
20 mM	0.1083 mL	0.5417 mL	1.0835 mL	5.4175 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc