Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 493.00 | |
100 mg | In stock | $ 723.00 | |
500 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption. |
In vitro | NS9283 increased the potency of varenicline to activate and desensitize α4β2?nAChRs in vitro without affecting other known targets of varenicline[2]. |
In vivo | In male and female C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss of the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake in both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversion[2]. |
Synonyms | NS 9283, NS-9283 |
Molecular Weight | 248.24 |
Formula | C14H8N4O |
CAS No. | 913830-15-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.06 mg/ml (12.31 mM)
You can also refer to dose conversion for different animals. More
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NS9283 913830-15-6 Neuroscience AChR Inhibitor Nicotinic acetylcholine receptors nAChR NS 9283 inhibit NS-9283 inhibitor