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NS1652

Catalog No. T16346 CAS 1566-81-0

NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.

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NS1652, CAS 1566-81-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 288.00
25 mg	In stock	$ 539.00
50 mg	In stock	$ 778.00
100 mg	In stock	$ 1,060.00
500 mg	In stock	$ 2,120.00

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Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
Targets&IC50	Cl- channel (human and mouse red blood cells):1.6 μM (IC50)
In vitro	NS1652 (20 μM) fully and reversibly inhibits the red cell Cl-conductance. NS1652 effectively inhibits the chloride conductance (IC50, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC50, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production (IC50: 3.1 μM in BV2 cells). NS1652 also down-regulates iNOS expression at 3 μM and fully abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) induces increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h [1][2].
In vivo	In mice, NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl- conductance by >90%[2].

Molecular Weight	324.25
Formula	C15H11F3N2O3
CAS No.	1566-81-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.9 mg/mL (15.11 mM), Sonification is recommended.

References and Literature

1. Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24. 2. Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood. 2000 Mar 1;95(5):1842-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Ion Channel Inhibitor Library ReFRAME Related Library Covalent Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Anti-Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NS1652 1566-81-0 Membrane transporter/Ion channel Chloride channel Cl? Channels inhibit Inhibitor Chloride Channel NS 1652 NS-1652 inhibitor

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