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NP213 TFA (942577-31-3 free base)

Catalog No. TP2149 CAS TP2149

Synonyms: NP213 TFA

NP213 TFA is a rapidly acting and first-in-class synthetic antimicrobial peptide (AMP) with anti-fungal activity. It targets the fungal cytoplasmic membrane via membrane perturbation and disruption.

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NP213 TFA (942577-31-3 free base) Chemical Structure

NP213 TFA (942577-31-3 free base), CAS TP2149

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Description	NP213 TFA is a rapidly acting and first-in-class synthetic antimicrobial peptide (AMP) with anti-fungal activity. It targets the fungal cytoplasmic membrane via membrane perturbation and disruption.
Targets&IC50	Fungal:
In vitro	NP213 (500-1000 μg/mL; 18 hours) increases the number of PI-stained T. rubrum NCPF0118 cells in samples [1]. NP213 shows different MIC values against T. rubrum NCPF0118, and the MICs varies depending on the source of the keratin. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin, and Lamb's wool Keratin, respectively [1].NP213 TFA (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus spp, and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 μg/ml [3].
In vivo	In Murine models of acute disseminated candidiasis, NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h. NP213 TFA (25 mg/kg) is well tolerated in mice [3].

Synonyms	NP213 TFA
Molecular Weight	1207.32
Formula	C44H85F3N28O9
CAS No.	TP2149

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mercer DK,et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18. 2. Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8(2):85-101. 3. Novamycin®/NP339 Technology Summary

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Keywords

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