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NIR-Thiol dinitrobenzenesulfonate

Catalog No. T19039 CAS T19039

NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. It is capable of imaging endogenously produced thiol in living cells and mice.

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NIR-Thiol dinitrobenzenesulfonate Chemical Structure

NIR-Thiol dinitrobenzenesulfonate, CAS T19039

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Biological Description

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Description	NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. It is capable of imaging endogenously produced thiol in living cells and mice.
In vitro	NIR-Thiol dinitrobenzenesulfonate is highly selective to typical small molecular weight biological thiols (Cys, Hcy, and GSH) over other biorelevant species, such as Phe, Gly, Arg, Lys, Tyr, Leu, glucose, Ser, and Val. The sensor NIR-Thiol dinitrobenzenesulfonate is incubated with living HeLa or Bel 7702 cells, and bright fluorescence is observed. NIR-Thiol dinitrobenzenesulfonate has some prominent features, including NIR absorption and emission, rapid response, high sensitivity, excellent selectivity, good cell membrane permeability, and low cytotoxicity.
In vivo	Varying doses (0, 20, 40, or 160 nmol) of NIR-Thiol dinitrobenzenesulfonate were administered intraperitoneally in mice, resulting in observable fluorescence intensity changes. Mice receiving the 20 nmol dose exhibited strong fluorescence, while control mice showed negligible fluorescence. Increasing the dosage to 40 or 160 nmol enhanced the fluorescence brightness significantly. Notably, a 700-fold increase in signal-to-noise contrast ratio was recorded for the 20 nmol dosage, which escalated to approximately 2900- and 7400-fold at 40 and 160 nmol dosages, respectively.

Molecular Weight	875.83
Formula	C39H33N5O15S2
CAS No.	T19039

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yuan L, et al. A unique approach to development of near-infrared fluorescent sensors for in vivo imaging. J Am Chem Soc. 2012 Aug 15;134(32):13510-23.

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