Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Monophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development.
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2 mg | Inquiry | $ 996.00 |
Description | Monophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development. |
In vitro | Monophosphoryl lipid A, at a concentration of 100 µg/ml for 2 hours, induces NF-κB activation and modulates TLR2 in dendritic cells, as evidenced by Western Blot Analysis. The same compound, ranging from 5 to 100 µg/ml over 24 hours, stimulates IL-12 production in human dendritic cells. Furthermore, increasing Monophosphoryl lipid A levels from 0.1 to 1 µg results in a higher percentage of matured bone marrow-derived dendritic cells (BMDCs). It also enhances cell surface markers on dendritic cells and boosts T cell responses, including the upregulation of calcium mobilization in activated CD4 T cells. |
In vivo | The synthesized Monophosphoryl lipid A activates antigen-presenting cells (APCs) and amplifies the production of Th1- and Th2-specific immune responses in mice[2]. |
Synonyms | Glucopyranosyl lipid A |
Molecular Weight | 1763.501 |
Formula | C96H184N3O22P |
CAS No. | 1246298-63-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Monophosphoryl lipid A 1246298-63-4 Glucopyranosyl lipid A inhibitor inhibit