Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 78.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 198.00 |
Description | Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively). |
In vitro | Dyrk inhibitor Mirk-IN-1 had an EC50 of 1.9 ±0.2 mmol/L on SW620 cells. Mirk-IN-1 inhibited the activities of DYRK1A, ABL, FLT3, and MARK1 by 88%, 64%, 56%, and 73%, respectively, at a much higher concentration of 10 mmol/L in a kinase assay [1]. Mirk-IN-1 was able to block tumour cells from undergoing reversible arrest in a quiescent G0 state and enable some cells to exit quiescence [2]. |
Synonyms | Dyrk1B/A-IN-1 |
Molecular Weight | 498.32 |
Formula | C23H17Cl2N5O4 |
CAS No. | 1386979-55-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (10.03 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Mirk-IN-1 1386979-55-0 Others MirkIN1 Dyrk1B/A-IN-1 Mirk IN 1 inhibitor inhibit