Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC 50 = 141 nM). However, it does not inhibit the growth of yeast expressing PKC.
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Description | Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC 50 = 141 nM). However, it does not inhibit the growth of yeast expressing PKC. |
In vitro | Mezerein, an antileukemic compound extracted from Daphne mezereum L, has demonstrated significant efficacy in inhibiting the proliferation of the tumorigenic murine macrophage cell line M5076, as shown in a Cell Proliferation Assay. When M5076 cells were treated with a concentration of 50 ng/mL of Mezerein for 72 hours, cellular proliferation was impeded by more than 90%. |
In vivo | Mezerein demonstrates significant antileukemic effects, specifically inhibiting P-388 lymphocytic leukemia and showing considerable activity against both P-388 and L-1210 leukemias in mice at a dosage of 50 μg/kg[2]. |
Molecular Weight | 654.712 |
Formula | C38H38O10 |
CAS No. | 34807-41-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mezerein 34807-41-5 inhibitor inhibit