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Methyl α-Linolenyl Fluorophosphonate

Catalog No. T22975 CAS T22975

Methyl α-Linolenyl Fluorophosphonate is an inhibitor of phospholipases. Methyl α-Linolenyl Fluorophosphonate (MLnFP), an analog of methyl Arachidonyl Fuorophosphonate (MAFP), has not been completely investigated for its pharmacological activity.

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Methyl α-Linolenyl Fluorophosphonate Chemical Structure

Methyl α-Linolenyl Fluorophosphonate, CAS T22975

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Biological Description

Chemical Properties

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Description

In vitro

In vitro: MethylArachidonyl Fluorophosphonate (MAFP) was reported to be a selective, active-site directed, irreversible inhibitor of cytosolic phospholipase A2 (cPLA2). MAFP could also potently inhibit the Ca2+-independent cytosolic phospholipase A2 (iPLA2) in a concentration-dependent manner. Such inhibition was not reversed upon extensive dilution of the enzyme into the assay mixture. The Preincubation of iPLA2 with MAFP led to a linear and time-dependent inactivation of enzyme activity, and the enzyme was protected from inactivation by the reversible inhibitor. The ability of MAFP to inhibit the iPLA 2 indicated that this enzyme proceeded via an acyl-enzyme intermediate. Further testing showed that MAFP could not inhibit the CoA-dependent acyltransferase, arachidonoyI-CoA synthetase, or CoA-independent transacylase activities. Therefore, MAFP was not a general inhibitor for enzymes acting on arachidonoyi substrates [1].

Molecular Weight	344.4
Formula	C19H34FO2P
CAS No.	T22975

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: ≤5mg/mL

DMSO: 5mg/ml

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Methyl α-Linolenyl Fluorophosphonate T22975 Others Methyl αLinolenyl Fluorophosphonate Methyl a-Linolenyl Fluorophosphonate Methyl α Linolenyl Fluorophosphonate Methyl alpha-Linolenyl Fluorophosphonate inhibitor inhibit

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