Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | 5 days | $ 378.00 |
Description | Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis. |
In vitro | Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1]. Melflufen hydrochloride induces apoptosis in MM.1S cells[1]. Melflufen hydrochloride also is a potent activator of exosome secretion[3]. Cell Viability Assay[1]Cell Line: Multiple myeloma cells: MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6 cells Concentration: 0.5, 1, 3, 5, 10 μM Incubation Time: 24 hours Result: A significant concentration-dependent decrease in viability of all cell lines was observed. |
In vivo | Melflufen (Melphalan flufenamide) hydrochloride, administered intravenously at a dosage of 3 mg/kg twice weekly for two weeks, demonstrates significant anti-multiple myeloma (MM) activity in a human plasmacytoma MM.1S xenograft mouse model using CB-17 SCID mice. This treatment notably inhibited MM tumor growth and extended the survival of the mice. |
Synonyms | Melflufen hydrochloride, Melphalan flufenamide hydrochloride |
Molecular Weight | 534.88 |
Formula | C24H31Cl3FN3O3 |
CAS No. | 380449-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Melflufen hydrochloride 380449-54-7 Melflufen Hydrochloride Melphalan flufenamide hydrochloride Melphalan flufenamide Hydrochloride inhibitor inhibit