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MTOB

Catalog No. T33519 CAS 51828-97-8

Synonyms: α-keto-γ-Methylthiobutyric acid, KMBA, MTOB salt, 4-methylthio 2-oxobutyric acid

MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MTOB, CAS 51828-97-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 75.00
5 mg	In stock	$ 111.00
10 mg	In stock	$ 153.00
25 mg	In stock	Inquiry
50 mg	In stock	Inquiry

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Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	α-keto-γ-Methylthiobutyric acid, KMBA, MTOB salt, 4-methylthio 2-oxobutyric acid
Molecular Weight	170.16
Formula	C5H7NaO3S
CAS No.	51828-97-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS: 100 mg/mL (587.68 mM), Sonication is recommended.

DMSO: 55 mg/mL (323.23 mM)

References and Literature

1. Dcona MM, Morris BL, Ellis KC, Grossman SR. CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors. Cancer Biol Ther. 2017 Jun 3;18(6):379-391. doi: 10.1080/15384047.2017.1323586. Epub 2017 May 22. PubMed PMID: 28532298; PubMed Central PMCID: PMC5536941. 2. Li M, Riddle S, Zhang H, D'Alessandro A, Flockton A, Serkova NJ, Hansen KC, Moldvan R, McKeon BA, Frid M, Kumar S, Li H, Liu H, Caánovas A, Medrano JF, Thomas MG, Iloska D, Plecitá-Hlavatá L, Ježek P, Pullamsetti S, Fini MA, El Kasmi KC, Zhang Q, Stenmark KR. Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation. 2016 Oct 11;134(15):1105-1121. Epub 2016 Aug 25. PubMed PMID: 27562971; PubMed Central PMCID: PMC5069179. 3. Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE Jr, Kellogg GE, Grossman SR, Ellis KC. Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). Bioorg Med Chem. 2016 Jun 15;24(12):2707-15. doi: 10.1016/j.bmc.2016.04.037. Epub 2016 Apr 20. PubMed PMID: 27156192; PubMed Central PMCID: PMC4993153. 4. Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE Jr. Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol. 2015 Apr 17;10(4):1118-27. doi: 10.1021/cb500820b. Epub 2015 Jan 30. PubMed PMID: 25636004; PubMed Central PMCID: PMC4844192.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MTOB 51828-97-8 Others alpha-keto-gamma-Methylthiobutyric acid CtBP MCF-7 α-keto-γ-Methylthiobutyric acid breast cancer traumatic brain injury inhibit KMBA MTOB salt Inhibitor a-keto-r-Methylthiobutyric acid neuroinflammation 4-methylthio 2-oxobutyric acid TBI inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.