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MPP dihydrochloride (289726-02-9 Free base)

Catalog No. T12101 CAS 911295-24-4

MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).

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MPP dihydrochloride (289726-02-9 Free base) Chemical Structure

MPP dihydrochloride (289726-02-9 Free base), CAS 911295-24-4

Pack Size	Availability	Price/USD
2 mg	5 days	$ 198.00
25 mg	6-8 weeks	$ 987.00
50 mg	6-8 weeks	$ 1,340.00
100 mg	6-8 weeks	$ 1,990.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).
In vitro	MPP dihydrochloride (20 μM; 24 h) reduces the phosphorylation of ERα, while it does not alter the phosphorylation of Akt. MPP dihydrochloride reduces the ratio of p-ERα/ERα[1].
In vivo	MPP results in a dose-dependent attenuation of the prepulse inhibition percentage[2].

Molecular Weight	542.5
Formula	C29H33Cl2N3O3
CAS No.	911295-24-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672. 2. Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.

Citations

1. Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2023: 1-12.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MPP dihydrochloride (289726-02-9 Free base) 911295-24-4 Others MPP dihydrochloride (289726029 Free base) MPP 289726-02-9 289726-02-9 Free base MPP dihydrochloride (289726 02 9 Free base) MPP Dihydrochloride inhibitor inhibit

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