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MIV-150

Catalog No. T16081 CAS 231957-54-3

Synonyms: PC 815

MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).

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MIV-150, CAS 231957-54-3

Pack Size	Availability	Price/USD
500 μg	35 days	$ 275.00
1 mg	35 days	$ 488.00
5 mg	35 days	$ 1,890.00
10 mg	35 days	$ 2,700.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).
Targets&IC50	HIV-2:<1 nM (EC50), HIV-1:<1 nM (EC50)
In vitro	MIV-150 demonstrates potent antiviral efficacy by inactivating free HIV virus with an EC50 of 0.004 μg/mL (or 0.01 μM), showcasing its high effectiveness against HIV, including strains resistant to other marketed antiretrovirals like Nevirapine, Delavirdine, and Efavirenz. Remarkably, resistance to MIV-150 develops slower compared to other anti-HIV drugs, as evident from in vitro studies where resistance to Nevirapine and Delavirdine emerged within 4 to 5 weeks, whereas resistance to MIV-150 took up to 45 weeks. Additionally, MIV-150's ability to protect target cells from infection was demonstrated through a syncytial assay, revealing an EC50 against HIV-1MN in CEM.SS cells below 1 nM, aligning with Medivir's findings.

Synonyms	PC 815
Molecular Weight	368.36
Formula	C19H17FN4O3
CAS No.	231957-54-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fernández-Romero JA, et al. Carrageenan/MIV-150 (PC-815), a combination microbicide. Sex Transm Dis. 2007 Jan;34(1):9-14.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MIV-150 231957-54-3 Others PC815 PC-815 PC 815 MIV 150 MIV150 inhibitor inhibit

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