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MHY908

Catalog No. T28035 CAS 1393371-39-5

MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.

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MHY908, CAS 1393371-39-5

Pack Size	Availability	Price/USD
500 μg	35 days	$ 120.00
1 mg	35 days	$ 198.00
10 mg	35 days	$ 1,270.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.

Molecular Weight	347.82
Formula	C17H14ClNO3S
CAS No.	1393371-39-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kim YR, Lee EK, Kim DH, Kim KM, Lee B, An HJ, Park JW, Moon KM, Park MH, Chung KW, Park JY, Kim SJ, Yun HY, Son S, Chun P, Moon HR, Chung HY. PPARα activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. Exp Gerontol. 2017 Jun;92:87-95. doi: 10.1016/j.exger.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28323024. 2. Park MH, Kim DH, Kim MJ, Lee EK, An HJ, Jeong JW, Kim HR, Kim SJ, Yu BP, Moon HR, Chung HY. Effects of MHY908, a New Synthetic PPARα/γ Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats. J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):300-9. doi: 10.1093/gerona/glv043. Epub 2015 Jul 28. PubMed PMID: 26219845. 3. Park MH, Kim SJ, Jeong HO, Moon KM, Son S, Kim DH, Kim HR, Kim MJ, Yun HY, Chun P, Je NK, Yokozawa T, Moon HR, Chung HY. Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch Pharm Res. 2015 Apr;38(4):505-11. doi: 10.1007/s12272-014-0532-0. Epub 2014 Dec 14. PubMed PMID: 25502981. 4. Park MH, Park JY, Lee HJ, Kim DH, Park D, Jeong HO, Park CH, Chun P, Moon HR, Chung HY. Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice. PLoS One. 2013 Nov 14;8(11):e78815. doi: 10.1371/journal.pone.0078815. eCollection 2013. PubMed PMID: 24244369; PubMed Central PMCID: PMC3828319.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MHY908 1393371-39-5 MHY 908 MHY-908 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.