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MGV354

Catalog No. T12888 CAS T12888

MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].

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MGV354, CAS T12888

Pack Size	Availability	Price/USD	Quantity
25 mg	10-14 weeks	$ 1,715.00
50 mg	10-14 weeks	$ 2,885.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].
In vitro	Treatment with MGV354, ranging from 0.1 nM to 10 μM, for one hour induces a dose-dependent elevation in cGMP levels within normal human trabecular meshwork (NTM) cells, showcasing an average effective concentration (EC50) of 2.5±1.6 nM after ODQ (20 μM) administration. The resultant average cGMP concentration achieved by MGV354 in NTM cells is 46±28 nM. Moreover, at a concentration of 1 μM, MGV354 consistently augments intracellular cGMP levels in NTM cells in a linear, time-dependent fashion, under assay conditions extending up to three hours [3].
In vivo	MGV354 (Compound (+)-23) robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop and has been selected for clinical evaluation [1].

Molecular Weight	575.7
Formula	C35H37N5O3
CAS No.	T12888

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570. 2. Stacy R, et al. A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma.Am J Ophthalmol. 2018 Aug;192:113-123. 3. Prasanna G, et al. A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing.Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1704-1716.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MGV354 T12888 Others MGV 354 MGV-354 inhibitor inhibit

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