Endocrinology/Hormones Thyroid hormone receptor(THR) MGL3196


Catalog No. T3595   CAS 920509-32-6
Synonyms: VIA-3196, Resmetirom

MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist.

MGL3196, CAS 920509-32-6
Pack Size Availability Price/USD Quantity
1 mg In stock 42.00
2 mg In stock 59.00
5 mg In stock 104.00
10 mg In stock 149.00
25 mg In stock 250.00
50 mg In stock 401.00
100 mg In stock 680.00
1 mL * 10 mM (in DMSO) In stock 99.00
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Purity 100.00%
Purity 99.13%
Biological Description
Chemical Properties
Storage & Solubility Information
Description MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist.
Targets&IC50 THR-β
In vivo MGL-3196 exhibits good exposures and reasonable oral bioavailability in rats. The volume of distribution and clearance are both low. Dose proportional increases in exposure are observed for a suspension of MGL-3196 given orally to DIO mice[1].In animals treated with MGL-3196 there is a reduction in cholesterol and in liver size, which is secondary to reduction of liver TG. There is no effect on bone mineral density (BMD) or heart or kidney size in MGL-3196 treated animals[1].
Synonyms VIA-3196 , Resmetirom
Purity 100.00%
Molecular Weight 435.22
Formula C17H12CL2N6O4
CAS No. 920509-32-6


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 31 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Kelly, M., Pietranico-Cole, S., Larigan, J., Haynes, N., Reynolds, C., & Scott, N. et al. (2014). Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia.?Journal Of Medicinal Chemistry,?57(10), 3912-3923. doi: 10.1021/jm4019299

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Clinical Compound Library Endocrinology-Hormones Library Anti-virus Compound Library Immunology/Inflammation Compound Library Anti-Cardiovascular Disease Compound Library Nuclear-receptor Inhibitors Library Drug Repurposing Library Anti-COVID-19 Compound Library

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