Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Dolastatin10 (a tubulin polymerization inhibitor) connected through the MC-Sq-Cit-PAB ADC linker.
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Description | MC-Sq-Cit-PAB-Dolastatin10 is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Dolastatin10 (a tubulin polymerization inhibitor) connected through the MC-Sq-Cit-PAB ADC linker. |
In vitro | ADC1-2 (anti-CD22 10F4v3 LC K149C MC-Sq-Cit-PAB-Dolastatin 10) demonstrates selective cytotoxicity against WSU-DLCL2 human diffuse large B-cell lymphoma tumors, achieving an IC50 value of 0.385 nM. Similarly, ADC1-1 (anti-Napi2b 10H1 11.4B LC K149C MC-Sq-Cit-PAB-Dolastatin 10) exhibits specific cytotoxic effects on human ovarian cancer cell lines IGROV-1 and OVCAR-3x2.1, with IC50 values of 3.19 nM and 1.52 nM, respectively[1]. |
Molecular Weight | 1338.72 |
Formula | C70H105N12O12S |
CAS No. | 1941168-65-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MC-Sq-Cit-PAB-Dolastatin10 1941168-65-5 Others MC Sq Cit PAB Dolastatin10 MC-Sq-Cit-PAB-Dolastatin-10 MCSqCitPABDolastatin10 inhibitor inhibit