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Endocrinology/Hormones Thyroid hormone receptor(THR) Levothyroxine sodium

Levothyroxine sodium

Catalog No. T22355   CAS 55-03-8
Synonyms: L-T4 sodium, L-Thyroxine sodium, LT4 sodium, LT4 sodium, L-Thyroxine sodium L-T4 sodium

Levothyroxine, the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.

Levothyroxine sodium, CAS 55-03-8
Pack Size Availability Price/USD Quantity
100 mg In stock 50.00
1 mL * 10 mM (in DMSO) In stock 79.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Levothyroxine, the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
Targets&IC50 Others,  
In vitro evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR[1]
In vivo
Cell Research
Cell lines: LS180V cells. Concentrations: 100 nM and 100μM. Incubation Time: 72 h. Method: LS180V cells are induced for 72 h with two l-T4 concentrations of 100 nM and 100 μM.
Animal Research
Animal Models: SD rats. Dosages: 20 μg/kg/day and 100 μg/kg/day. Administration: i.p.
Animal Research
Animal Models: SD rats. Dosages: 20 μg/kg/day and 100 μg/kg/day. Administration: i.p.
Animal Model:
Cell Research
Cell lines: LS180V cells. Concentrations: 100 nM and 100μM. Incubation Time: 72 h. Method: LS180V cells are induced for 72 h with two l-T4 concentrations of 100 nM and 100 μM.
Cell lines:
Synonyms L-T4 sodium , L-Thyroxine sodium , LT4 sodium , LT4 sodium , L-Thyroxine sodium L-T4 sodium
Purity 98.00%
Molecular Weight 798.85
Formula C15H10I4NO4.Na
CAS No. 55-03-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 100 mg/ml (125.18 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Mitin T, et al. Drug Metab Dispos. 2004, 32(8):779-82. 2. Stéphanie Corriveau MSc, et al. Journal of Clinical & Translational Endocrinology. 2015, 2(4):144-149. 3. Philippe Colucci, et al. European Endocrinology. 2013, 9(1):40-47

Related Products

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Taltirelin acetate KAT681 L-Thyroxine sodium salt pentahydrate CO23 Levothyroxine sodium MGL3196 Liothyronine sodium O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine

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