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Leukotriene C4

Catalog No. T25687 CAS 72025-60-6

Synonyms: LTC4, Leukotriene C

Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion in the lung and produces contractions of nonvascular and some vascular smooth muscle.

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Leukotriene C4, CAS 72025-60-6

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	LTC4, Leukotriene C
Molecular Weight	625.77
Formula	C30H47N3O9S
CAS No.	72025-60-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dvash E, Har-Tal M, Barak S, Meir O, Rubinstein M. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Nat Commun. 2015 Dec 11;6:10112. doi: 10.1038/ncomms10112. PubMed PMID: 26656251; PubMed Central PMCID: PMC4682057. 2. MacDonald CA, Bushnell EA, Gauld JW, Boyd RJ. The catalytic formation of leukotriene C4: a critical step in inflammatory processes. Phys Chem Chem Phys. 2014 Aug 14;16(30):16284-9. doi: 10.1039/c4cp01984a. PubMed PMID: 24974917. 3. Yonetomi Y, Sekioka T, Kadode M, Kitamine T, Kamiya A, Matsumura N, Fujita M, Kawabata K. Leukotriene C4 induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs. Eur J Pharmacol. 2015 May 5;754:98-104. doi: 10.1016/j.ejphar.2015.02.014. Epub 2015 Feb 20. PubMed PMID: 25704617. 4. Hirata H, Arima M, Fukushima Y, Sugiyama K, Tokuhisa T, Fukuda T. Leukotriene C4 aggravates bleomycin-induced pulmonary fibrosis in mice. Respirology. 2013 May;18(4):674-81. doi: 10.1111/resp.12072. PubMed PMID: 23432979.

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Keywords

Leukotriene C4 72025-60-6 Leukotriene C-4 LTC 4 LTC4 Leukotriene C LTC-4 inhibitor inhibit

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