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Lenalidomide-C4-NH2 hydrochloride

Catalog No. T17878 CAS T17878

Synonyms: Cereblon ligand 1 hydrochloride, E3 ligase Ligand-Linker Conjugates 32 hydrochloride

Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].

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Lenalidomide-C4-NH2 hydrochloride Chemical Structure

Lenalidomide-C4-NH2 hydrochloride, CAS T17878

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2 mg	5 days	$ 44.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Cereblon ligand 1 hydrochloride, E3 ligase Ligand-Linker Conjugates 32 hydrochloride
Molecular Weight	351.83
Formula	C17H22ClN3O3
CAS No.	T17878

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 130 mg/mL (369.50 mM), Sonication is recommended.

References and Literature

1. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lenalidomide-C4-NH2 hydrochloride T17878 Others Lenalidomide C4 NH2 hydrochloride Cereblon ligand 1 hydrochloride Lenalidomide-C-4-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 32 hydrochloride Cereblon ligand 1 Hydrochloride LenalidomideC4NH2 hydrochloride Lenalidomide-C4-NH2 Hydrochloride inhibitor inhibit

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