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Lemildipine

Catalog No. T15733 CAS 94739-29-4

Synonyms: NB-818, NPK-1886

Lemildipine is a new blocker of dihydropyridine calcium entry.

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Lemildipine, CAS 94739-29-4

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 376.00
25 mg	6-8 weeks	$ 1,140.00
50 mg	6-8 weeks	$ 1,490.00
100 mg	6-8 weeks	$ 2,360.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Lemildipine is a new blocker of dihydropyridine calcium entry.

In vivo

Lemildipine produces a significant decrease in the blood pressure of spontaneously hypertensive rats (SHR). Lemildipine is 1.4 times stronger than Nifedipine; the ED30 values of Lemildipine and Nifedipine are 10.2 mg/kg and 14.3 mg/kg, respectively[2]. Gerbils are treated intraperitoneally with Lemildipine (0.1-3 mg/kg) just after release of the occlusion. Four days after the ischemia, they are fixed by perfusing 10% buffered-formalin, and the neuronal cell density (NCD, cell/mm) in the CA1 subfield is estimated under microscopy. The average NCD in the ischemic control group is 43±10.8 cells/mm, whereas Lemildipine (3 mg/kg) significantly ameliorates DND with an average NCD of 143±24.2 cells/mm (P<0.01). Lemildipine (3-30 mg/kg; p.o.), in normal Wistar rats (NWR), produces a mild lowering of blood pressure. Lemildipine(p.o.; 3, 10, 30 mg/kg) produces a significant decrease in systolic blood pressure dose-dependently. Lemildipine (3 mg/kg) significantly inhibits delayed neuronal death (DND) at 1, 2 and 4 weeks after transient ischemia: the average NCD of the Lemildipine and ischemic control groups are 80±9.4 (P<0.01) and 43±7.7 cells/mm, 92±13.7 (P<0.05) and 52±9.3 cells/mm, and 57±5.0 (P<0.01) and 43±12.4 cells/mm, respectively. Lemildipine shows a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, in this experiment, and its effect persisted for up to 4 weeks[1]. The maximum decrease is observed 1-3 hr after administration. Comparing the hypotensive potency of Lemildipine and Nifedipine, their dose-response curves at the maximum response during the observation (for 24 hr) are analyzed by the least squares method, and the dose of 30% decrease in blood pressure from the control level (ED30) are used as a measure of their potency.

Synonyms	NB-818, NPK-1886
Molecular Weight	457.3
Formula	C20H22Cl2N2O6
CAS No.	94739-29-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kamei K, et al. Effect of a new calcium entry blocker, NB-818, on delayed neuronal death in the ischemic gerbil hippocampus. Jpn J Pharmacol. 1991 Jul;56(3):279-86. 2. Nagura J, et al. Cardiovascular effects of NPK-1886, a new dihydropyridine compound with calcium entry blocking activity. Jpn J Pharmacol. 1986 Mar;40(3):399-409.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lemildipine 94739-29-4 Others NPK1886 NB 818 NB818 NB-818 NPK-1886 NPK 1886 inhibitor inhibit

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