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Lecimibide

Catalog No. T25651 CAS 130804-35-2

Synonyms: DuP128, DuP-128, DuP 128

Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids.

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Lecimibide, CAS 130804-35-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 146.00
5 mg	In stock	$ 350.00
10 mg	In stock	$ 530.00
25 mg	In stock	$ 859.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,590.00
500 mg	In stock	$ 3,190.00

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Purity: 99.74%

Purity: 99.45%

Biological Description

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Description	Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids.
In vitro	Lecimibide (DuP 128) (10 μM; 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells.[1]
In vivo	Lecimibide (DuP 128) (2.2 mg/kg/day.; i.v) significantly reduced total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol, respectively 36% and 31%. There were no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apo B concentrations.[2]

Synonyms	DuP128, DuP-128, DuP 128
Molecular Weight	590.77
Formula	C34H40F2N4OS
CAS No.	130804-35-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wilcox LJ, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001;42(5):725-734. 2. Burnett JR, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998;1393(1):63-79. 3. Hainer JW, Terry JG, Connell JM, Zyruk H, Jenkins RM, Shand DL, Gillies PJ, Livak KJ, Hunt TL, Crouse JR 3rd. Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans. Clin Pharmacol Ther. 1994 Jul;56(1):65-74. PubMed PMID: 8033496. 4. Miyazaki A, Horiuchi S. [ACAT inhibitors]. Nihon Rinsho. 2001 Mar;59 Suppl 3:675-80. Review. Japanese. PubMed PMID: 11347152.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Nevanimibe hydrochloride Cyclandelate 24-Methylenecholesterol PF-06424439 methanesulfonate PF-06424439 Xanthohumol BAY-3827 PF-04620110

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lecimibide 130804-35-2 Metabolism Acyltransferase DuP128 DuP-128 DuP 128 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.