Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays <5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 35 days | $ 668.00 | |
50 mg | 35 days | $ 2,800.00 |
Description | Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model. |
Molecular Weight | 426.87 |
Formula | C18H17ClF2N4O2S |
CAS No. | 1262036-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.69 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LY 2886721 Hydrochloride 1262036-49-6 LY2886721 Hydrochloride LY-2886721 Hydrochloride inhibitor inhibit