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LY2183240

Catalog No. T15802 CAS 874902-19-9

LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).

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LY2183240, CAS 874902-19-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 64.00
25 mg	In stock	$ 133.00
50 mg	In stock	$ 253.00
100 mg	In stock	$ 396.00
500 mg	In stock	$ 929.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 98.17%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).
Targets&IC50	FAAH:12.4 nM
In vitro	LY2183240 increases brain anandamide concentration and exerts antinociceptive effects in the formalin model of pain, anandamide uptake Following i.p. administration in rats.

Molecular Weight	307.35
Formula	C17H17N5O
CAS No.	874902-19-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (162.68 mM), Sonication is recommended.

References and Literature

1. Dickason-Chesterfield AK, et al. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):407-23. 2. Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814. 3. Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J Am Chem Soc. 2006 Aug 2;128(30):9699-704. 4. Maione S, et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol. 2008 Nov;155(5):775-82. 5. Pelorosso FG, et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. Eur J Pharmacol. 2009 Jan 5;602(1):176-9. 6. Powers MS, et al. Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference. Psychopharmacology (Berl). 2010 Dec;212(4):571-83.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Neuronal Signaling Compound Library Lipid Metabolism Compound Library Anti-Obesity Compound Library Anti-Metabolism Disease Compound Library Autophagy Compound Library NO PAINS Compound Library Metabolism Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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CB2R/FAAH modulator-2 FAAH-IN-1 URB937 JP104 SA 47 N-Benzylpalmitamide 1-Monomyristin 2-Chlorophenylboronic acid

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY2183240 874902-19-9 Autophagy Metabolism Neuroscience FAAH Inhibitor brain uptake transport hydrolases Fatty acid amide hydrolase LY 2183240 serine LY-2183240 anandamide inhibit inhibitor

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