Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).
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Description | LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). |
In vitro | In the in vitro signal transduction experiments, LITL-001 free Base is an unbiased OT-R agonist that ACTS on the two main signal transduction pathways of the receptor and has a slight antagonistic effect on V1a and an agonist effect on V1b receptor, which is only observed at high concentration. |
In vivo | LIT-001 free base (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. |
Molecular Weight | 531.67 |
Formula | C28H33N7O2S |
CAS No. | 2245072-20-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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