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L-NIL

Catalog No. T11805 CAS 53774-63-3

L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO synthase, respectively.

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L-NIL, CAS 53774-63-3

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10 mg	In stock	$ 42.00

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Description	L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO synthase, respectively.
Targets&IC50	iNOS (mouse):3.3 μM , cNOS (rat brain):92 μM
In vitro	L-NIL exhibits 28-fold higher selectivity for mouse inducible NOS (miNOS) over rat brain constitutive NOS (rcNOS), with IC50 values of 3.3 pM and 92 pM, respectively. Furthermore, it demonstrates roughly 6 times more potency towards miNOS compared to both L-NMA and L-NNA. The compound effectively inhibits miNOS and rcNOS in a concentration-dependent manner, showcasing significant potency for miNOS.
In vivo	L-NIL protects the integrity of the tarsal, talus and calcaneus bones as well as the soft tissue surrounding the joint, while adjuvant controls exhibit severe deterioration of these bones and dramatic soft tissue swelling.?L-NIL limits progression of preexisting atherosclerosis in hypercholesterolemic rabbits.?Increased intimal collagen accumulation may participate in iNOS-induced atherosclerosis progression.L-NIL may prove particularly useful in determining the role of nitric oxide production by inducible NOS in models of chronic inflammation (e.g., adjuvant arthritis).?L-NIL suppresses the increase in plasma nitrite levels and joint inflammation associated with adjuvant-induced arthritis in a dose-dependent manner.?L-NIL attenuates the inducible nitric oxide synthase immunoreactivity in adjuvant-treated rats.

Molecular Weight	187.24
Formula	C8H17N3O2
CAS No.	53774-63-3

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Moore WM, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. 2. Connor JR, et al. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol. 1995 Jan 24;273(1-2):15-24. 3. Behr-Roussel D, et al. Effect of chronic treatment with the inducible nitric oxide synthase inhibitor N-iminoethyl-L-lysine or with L-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits. Circulation. 2000 Aug 29;102(9):1033-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-NIL 53774-63-3 Others L NIL LNIL inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.