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L-Homocysteine thiolactone hydrochloride

Catalog No. T19393 CAS 31828-68-9

L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine,It prevents translational incorporation of homocysteine into proteins.

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L-Homocysteine thiolactone hydrochloride Chemical Structure

L-Homocysteine thiolactone hydrochloride, CAS 31828-68-9

Pack Size	Availability	Price/USD
2 mg	5 days	$ 46.00
5 mg	5 days	$ 77.00
10 mg	5 days	$ 117.00
25 mg	5 days	$ 196.00
50 mg	5 days	$ 318.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine,It prevents translational incorporation of homocysteine into proteins.
In vitro	Homocysteine thiolactone, a metabolite of homocysteine, exhibits cytotoxic properties and triggers apoptosis in HL-60 cells, as evidenced by increased phosphatidylserine exposure, hypoploid DNA content, internucleosomal DNA fragmentation, caspase-3 activation, and DNA fragmentation. Additionally, it significantly promotes IL-8 release. Conversion of homocysteine to homocysteine thiolactone by methionyl-tRNA synthetase happens across all cell types, from bacterial to human, including endothelial cells. Elevated homocysteine levels are recognized as an independent cardiovascular disease risk factor due to its conversion to the reactive thioester, homocysteine thiolactone, harmful to human cells.
In vivo	Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.?Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer's disease.

Molecular Weight	153.63
Formula	C4H8ClNOS
CAS No.	31828-68-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 23 mg/mL (149.71 mM)

References and Literature

1. Jakubowski H, et al. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2000 Feb;130(2S Suppl):377S-381S. 2. Huang RF, et al. Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellularhydrogen peroxide and caspase 3 activation in HL-60 cells. Life Sci. 2001 May 11;68(25):2799-811. 3. Kerkeni M, et al. Comparative study on in vitro effects of homocysteine thiolactone and homocysteine on HUVECcells: evidence for a stronger proapoptotic and proinflammative homocysteine thiolactone. Mol Cell Biochem. 2006 Oct;291(1-2):119-26. 4. Borowczyk K, et al. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. J Alzheimers Dis. 2012;30(2):225-31. 5. Stanojlović O, et al. Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study. Cell Mol Neurobiol. 2009 May;29(3):329-39.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-Homocysteine thiolactone hydrochloride 31828-68-9 Others LHomocysteine thiolactone hydrochloride L-Homocysteine thiolactone Hydrochloride L Homocysteine thiolactone hydrochloride inhibitor inhibit

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