Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-690330 is a competitive inositol monophosphatase inhibitor (Kis: 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase). L-690330 shows 10-fold more sensitive than a mouse and rat IMPase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mL * 10 mM (in DMSO) | 5 days | $ 143.00 |
Description | L-690330 is a competitive inositol monophosphatase inhibitor (Kis: 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase). L-690330 shows 10-fold more sensitive than a mouse and rat IMPase. |
Targets&IC50 | IMPase (bovine recombinant):0.19 μM(ki), IMPase (bovine frontal cortex):0.42 μM, IMPase (human recombinant):(ki)0.27 μM, IMPase (human frontal cortex):0.30 μM(ki) |
In vitro | In HEK293 cells, L-690330 (50 μM; 1 hour) causes P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression[2]. |
In vivo | Except for a reduction in time spent in light in the dark/light test, L-690330 (intracerebroventricular?injection; 0.1 μmol) shows no effects on their motor activity and coordination in the beam walking [3]. |
Molecular Weight | 298.12 |
Formula | C8H12O8P2 |
CAS No. | 142523-38-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 33.33 mg/mL (111.80 mM), Sonication is recommended.
DMSO: 25 mg/mL (83.86 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
L-690330 142523-38-4 Others L 690330 L690330 inhibitor inhibit