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L-2-Phosphoglyceric acid disodium salt hydrate

Catalog No. T5141 CAS T5141

L-2-Phosphoglyceric acid disodium salt is a glyceric acid which serves as the substrate in glycolysis. It is catalyzed by enolase into phosphoenolpyruvate.

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L-2-Phosphoglyceric acid disodium salt hydrate Chemical Structure

L-2-Phosphoglyceric acid disodium salt hydrate, CAS T5141

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

L-2-Phosphoglyceric acid disodium salt is a glyceric acid which serves as the substrate in glycolysis. It is catalyzed by enolase into phosphoenolpyruvate.

In vivo

SRT1720 (10, 30, 100 mg/kg, p.o.) significantly reduces the hyperinsulinemia after 4 weeks, partially normalizing elevated insulin levels similar to rosiglitazone treatment. SRT1720 treatment significantly reduces fasting blood glucose to near normal levels in Lepob/ob mice[1]. SRT1720 has the ability to protect against the negative effects of diet-induced obesity in mice and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1[2]. SRT1720 (50-100 mg/kg, p.o.), during emphysema development, attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice [3].

Molecular Weight	230.02
Formula	C3H5Na2O7P · xH2O
CAS No.	T5141

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Reed GH, et al. Structural and mechanistic studies of enolase. Curr Opin Struct Biol. 1996 Dec;6(6):736-43.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L-2-Phosphoglyceric acid disodium salt hydrate T5141 Others L2Phosphoglyceric acid disodium salt hydrate L 2 Phosphoglyceric acid disodium salt hydrate L-2-Phosphoglyceric acid disodium Hydrate inhibitor inhibit

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