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L 674573

Catalog No. T24327 CAS 127481-29-2

Synonyms: L 674,573, L674573, L674,573, L-674,573, L-674573

L 674573 is an inhibitor of leukotriene biosynthesis.

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L 674573, CAS 127481-29-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L 674573 is an inhibitor of leukotriene biosynthesis.
In vitro	L-674,573 specifically inhibits labeling of an 18-kDa protein, in a concentration dependent manner with IC50 of 70nM [1].

Synonyms	L 674,573, L674573, L674,573, L-674,573, L-674573
Molecular Weight	457.58
Formula	C28H27NO3S
CAS No.	127481-29-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mancini JA, Prasit P, Coppolino MG, Charleson P, Leger S, Evans JF, Gillard JW, Vickers PJ. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. PubMed PMID: 1538707. 2. Kargman S, Prasit P, Evans JF. Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. J Biol Chem. 1991 Dec 15;266(35):23745-52. PubMed PMID: 1748650.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

L 674573 127481-29-2 L674573 L-674,573 L-674573 Inhibitor inhibitor inhibit

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