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KT5926

Catalog No. T24272 CAS 126643-38-7

Synonyms: KT 5926, KT-5926

KT5926 is an effective and selective inhibitor of myosin light chain kinase. KT5926 is an analogue of K-252a, which blocks all responses to NGF. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation.

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KT5926, CAS 126643-38-7

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 3,320.00
50 mg	10-14 weeks	$ 4,380.00
100 mg	10-14 weeks	$ 6,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	KT 5926, KT-5926
Molecular Weight	525.55
Formula	C30H27N3O6
CAS No.	126643-38-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kim YS, Kawai A. Studies on the antiviral mechanisms of protein kinase inhibitors K-252a and KT5926 against the replication of vesicular stomatitis virus. Biol Pharm Bull. 1998 May;21(5):498-505. PubMed PMID: 9635507. 2. Oberstar JV, Challacombe JF, Roche FK, Letourneau PC. Concentration-dependent stimulation and inhibition of growth cone behavior and neurite elongation by protein kinase inhibitors KT5926 and K-252a. J Neurobiol. 1997 Aug;33(2):161-71. PubMed PMID: 9240372. 3. Abraham I, Wolf CL, Sampson KE, Laborde AL, Shelly JA, Aristoff PA, Skulnick HI. K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel. Cancer Res. 1994 Nov 15;54(22):5889-94. PubMed PMID: 7954419. 4. Teng KK, Greene LA. KT5926 selectively inhibits nerve growth factor-dependent neurite elongation. J Neurosci. 1994 May;14(5 Pt 1):2624-35. PubMed PMID: 8182431.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KT5926 126643-38-7 KT 5926 KT-5926 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.