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KNT-127

Catalog No. T25583 CAS 1256921-89-7

KNT-127 is an agonist of δ-Opioid receptor.

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KNT-127, CAS 1256921-89-7

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,270.00
50 mg	10-14 weeks	$ 2,980.00
100 mg	10-14 weeks	$ 4,000.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

KNT-127 is an agonist of δ-Opioid receptor.

Molecular Weight	372.46
Formula	C24H24N2O2
CAS No.	1256921-89-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H. Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice. Pharmacol Rep. 2018 Apr;70(2):350-354. doi: 10.1016/j.pharep.2017.08.018. Epub 2017 Oct 28. PubMed PMID: 29477045. 2. Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M. The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice. Behav Brain Res. 2018 Jan 15;336:77-84. doi: 10.1016/j.bbr.2017.08.041. Epub 2017 Aug 31. PubMed PMID: 28864205. 3. Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M. Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Behav Brain Res. 2017 Apr 14;323:11-14. doi: 10.1016/j.bbr.2016.11.008. Epub 2016 Dec 1. PubMed PMID: 27916688. 4. Saitoh A, Nagase H. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept. Handb Exp Pharmacol. 2016 Oct 28. doi: 10.1007/164_2016_18. [Epub ahead of print] PubMed PMID: 27787711.

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecule Formula

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KNT-127 1256921-89-7 KNT127 KNT 127 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.