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KIN1148

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Synonyms:

Catalog No. T4027 Copy Product Info

Purity: 97.29%

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KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection. The adjuvant will be developed for an FDA-approved avian inluenza virus vaccine as well as evaluation in flavivirus vaccine platforms, including West Nile virus, because of the small molecules broad immune-enhancing activity.

Cas No. 1428729-56-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$147	In Stock	In Stock
5 mg	$278	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$653	In Stock	In Stock
50 mg	$868	In Stock	In Stock
100 mg	$1,160	In Stock	In Stock
200 mg	$1,560	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:97.29%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	361.44
Formula	C₁₉H₁₁N₃OS₂
Cas No.	1428729-56-9
Smiles	O=C(Nc1nc2ccc3scnc3c2s1)c1ccc2ccccc2c1
Relative Density.	1.531 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (69.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% (20% SBE-β-CD in Saline): < 2.5 mg/mL (6.92 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% Corn oil: < 2.5 mg/mL (6.92 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: < 2.5 mg/mL (6.92 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% Saline: < 2.5 mg/mL (6.92 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7667 mL	13.8336 mL	27.6671 mL	138.3355 mL
5 mM	0.5533 mL	2.7667 mL	5.5334 mL	27.6671 mL
10 mM	0.2767 mL	1.3834 mL	2.7667 mL	13.8336 mL
20 mM	0.1383 mL	0.6917 mL	1.3834 mL	6.9168 mL
50 mM	0.0553 mL	0.2767 mL	0.5533 mL	2.7667 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc