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JTV-803 mesylate

Catalog No. T27698 CAS 247131-79-9

Synonyms: JTV803, JTV 803, JTV-803

JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting human factor Xa as compared to its inhibitory activity against thrombin, trypsin and plasmin. JTV-803 prolonged activated partial thromboplastin time and prothrombin time in a dose-dependent manner.

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JTV-803 mesylate, CAS 247131-79-9

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 2,120.00
50 mg	8-10 weeks	$ 2,780.00
100 mg	8-10 weeks	$ 3,700.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	JTV803, JTV 803, JTV-803
Molecular Weight	505.59
Formula	C23H31N5O6S
CAS No.	247131-79-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gerotziafas GT, Samama MM. Heterogeneity of synthetic factor Xa inhibitors. Curr Pharm Des. 2005;11(30):3855-76. Review. PubMed PMID: 16305517. 2. Ueno H, Yokota K, Hoshi J, Yasue K, Hayashi M, Hase Y, Uchida I, Aisaka K, Katoh S, Cho H. Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring. J Med Chem. 2005 May 19;48(10):3586-604. PubMed PMID: 15887966. 3. Ueno H, Yokota K, Hoshi J, Yasue K, Hayashi M, Uchida I, Aisaka K, Hase Y, Katoh S, Cho H. Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors. Bioorg Med Chem Lett. 2005 Jan 3;15(1):185-9. PubMed PMID: 15582437. 4. Tobu M, Iqbal O, Hoppensteadt D, Neville B, Messmore HL, Fareed J. Anti-Xa and anti-IIa drugs alter international normalized ratio measurements: potential problems in the monitoring of oral anticoagulants. Clin Appl Thromb Hemost. 2004 Oct;10(4):301-9. PubMed PMID: 15497016.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JTV-803 mesylate 247131-79-9 JTV803 JTV 803 Mesylate JTV 803 JTV803 Mesylate JTV-803 JTV 803 mesylate JTV803 mesylate JTV-803 Mesylate inhibitor inhibit

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