Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
2 mg | In stock | $ 88.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 222.00 | |
25 mg | In stock | $ 396.00 | |
50 mg | In stock | $ 592.00 | |
100 mg | In stock | $ 822.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1. |
Targets&IC50 | IRAK1:9 nM |
In vitro | JH-X-119-01 exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88.?Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. |
Molecular Weight | 452.46 |
Formula | C25H20N6O3 |
CAS No. | 2227368-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/ml (26.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JH-X-119-01 2227368-54-7 Immunology/Inflammation NF-Κb IRAK inhibit MYD88 IL-1R associated kinase Waldenstr?m Inhibitor IRAK1 Interleukin-1 receptor associated kinase JHX11901 Diffused Large B-cell Lymphoma JH X 119 01 macroglobulinemia inhibitor