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Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]

Catalog No. TP2260 CAS TP2260

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] is a fragment (Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg) on the human immunoglobulin micro heavy chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions.

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Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] Chemical Structure

Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens], CAS TP2260

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Biological Description

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Storage & Solubility Information

Description

In vitro

The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.

Molecular Weight	1774.07
Formula	C82H132N24O20
CAS No.	TP2260

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keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] TP2260 Others inhibitor inhibit

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