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Imexon

Catalog No. T15566 CAS 59643-91-3

Synonyms: BM 06002

Imexon is an iminopyrrolidone aziridine. It has anti-cancer activity.

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Imexon, CAS 59643-91-3

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 2,120.00
50 mg	8-10 weeks	$ 2,780.00
100 mg	8-10 weeks	$ 3,700.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Imexon is an iminopyrrolidone aziridine. It has anti-cancer activity.
In vitro	Imexon induces single-stranded breaks in the human A375 melanoma cells but only obviously at the highest concentrations for each agent compared to controls. Imexon causes oxidative stress in the ER, activates an ER stress response. Imexon does not obviously alter the levels of eIF2B5, however, there is a dose-dependent increase in the phosphorylation of eIF2alpha, as well as an increase in the levels of GTP exchange protein eIF2B2 in MiaPaCa-2, Panc-1, and BxPC3 cells[1]. Imexon plus DTIC cytotoxicity is additive[2]. Imexon display inhibitory activities against MiaPaCa-2, Panc-1 and BxPC3, (IC50s: 275.5 ± 54.2, 147.4 ± 4.7 and 355.7 ± 114.7 μM).[3].
In vivo	When administered at 100 mg/kg, Imexon demonstrates enhanced efficacy in suppressing Panc-1 tumor growth in SCID mice when used alongside GEM, evidencing a synergistic effect. Concurrently, pairing Imexon with DTIC elevates peak plasma levels of Imexon in mice without tumors. This drug duo also augments the plasma Imexon area under the curve (AUC) by 22% (p=0.026). Despite this, a regimen of Imexon (100 mg/kg/day, intravenously) leads to weight loss in SCID mice carrying human A375 melanoma tumors, without significantly impacting tumor progression[2].

Synonyms	BM 06002
Molecular Weight	111.1
Formula	C4H5N3O
CAS No.	59643-91-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Sheveleva EV, et al. Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res. 2012 Mar;10(3):392-400. 2. Samulitis BK, et al. Interaction of dacarbazine and imexon, in vitro and in vivo, in human A375 melanoma cells. Anticancer Res. 2011 Sep;31(9):2781-5. 3. Roman NO, et al. Imexon enhances gemcitabine cytotoxicity by inhibition of ribonucleotide reductase. Cancer Chemother Pharmacol. 2011 Jan;67(1):183-92.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Imexon 59643-91-3 Others BM 06002 BM06002 BM-06002 inhibitor inhibit

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