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Idoxuridine hydrate

Catalog No. T61492 CAS 17140-71-5

Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].

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Idoxuridine hydrate, CAS 17140-71-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 2,140.00
50 mg	6-8 weeks	$ 2,785.00
100 mg	6-8 weeks	$ 3,520.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Idoxuridine hydrate (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is a competitive inhibitor of phosphorylases. As an iodinated thymidine analogue, it effectively inhibits DNA polymerase and hinders viral replication, making it useful in the treatment of viral eye infections such as herpes simplex keratitis. Against feline herpesvirus, Idoxuridine has been found to have an IC50 value of 4.3 μM [1].
In vitro	Idoxuridine hydrate, at concentrations ranging between 2-10 μM over a 72-hour period, exhibits an antiviral IC50 value of 4.3 μM, as demonstrated in a Cell Proliferation Assay on Crandell-Reese feline kidney (CRFK) cells. Additionally, a Cell Cytotoxicity Assay revealed that exposure to concentrations of 5-50 μM for the same duration resulted in a relative reduction of 10.8% in CRFK cell viability.
In vivo	Idoxuridine hydrate, administered through intraperitoneal injection at a dosage of 50-200 mg/kg for three times at three-hour intervals, has been shown to enhance the production of hemolysin plaque-forming cells (HPFC) against sheep red blood cells (SRBC) in both female and male C3HeB/FeJ mice as well as A/J male mice. This effect was observed across the specified dosage range.

Molecular Weight	372.115
Formula	C9H13IN2O6
CAS No.	17140-71-5

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Idoxuridine hydrate 17140-71-5 inhibitor inhibit

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