Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iclepertin (BI-425809) is a highly effective, selective, and orally bioavailable inhibitor of glycine transporter 1 (GlyT1). It exhibits no activity against GlyT2. Consequently, Iclepertin holds promise for advancing research on Alzheimer's disease and schizophrenia [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 226.00 | |
2 mg | In stock | $ 337.00 | |
5 mg | In stock | $ 562.00 | |
10 mg | In stock | $ 892.00 | |
25 mg | In stock | $ 1,990.00 | |
50 mg | In stock | $ 3,270.00 | |
100 mg | In stock | $ 5,200.00 |
Description | Iclepertin (BI-425809) is a highly effective, selective, and orally bioavailable inhibitor of glycine transporter 1 (GlyT1). It exhibits no activity against GlyT2. Consequently, Iclepertin holds promise for advancing research on Alzheimer's disease and schizophrenia [1]. |
Targets&IC50 | GLT1:5 nM (IC50, In human SK-N-MC cells), GLT1:5.2 mM (IC50, In rat primary neurons) |
In vitro | Iclepertin effectively inhibits GlyT1, demonstrating IC50 values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells[1]. |
In vivo | Single oral administration of Iclepertin in rats has been shown to induce a dose-dependent elevation in glycine levels within the cerebrospinal fluid (CSF), ranging from a 30% increase at a dose of 0.2 mg/kg, which was not statistically significant, to a significant 78% increase at a dose of 2 mg/kg, relative to a control vehicle[1]. |
Molecular Weight | 512.42 |
Formula | C20H18F6N2O5S |
CAS No. | 1421936-85-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Iclepertin 1421936-85-7 inhibitor inhibit