Powder: -20°C for 3 years
In solvent: -80°C for 2 years
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
Description | INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively. |
Targets&IC50 | DYRK1B:0.23 μM, DYRK1A:(ki)0.18 μM, DYRK1A:0.24 μM |
In vitro | INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM[1]. |
In vivo | In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently[1]. |
Molecular Weight | 235.3 |
Formula | C12H13NO2S |
CAS No. | 1169755-45-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 5 mg/mL (21.25 mM), ultrasonic and warming and heat to 60°C
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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INDY 1169755-45-6 蛋白酪氨酸激酶 细胞周期 DYRK Inhibitor inhibitor inhibit