Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 73.00 | |
25 mg | In stock | $ 113.00 | |
50 mg | In stock | $ 161.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 59.00 |
Description | INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively. |
Targets&IC50 | DYRK1B:0.23 μM, DYRK1A:(ki)0.18 μM, DYRK1A:0.24 μM |
In vitro | INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM[1]. |
In vivo | In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently[1]. |
Synonyms | 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one |
Molecular Weight | 235.3 |
Formula | C12H13NO2S |
CAS No. | 1169755-45-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (21.25 mM), ultrasonic and warming and heat to 60°C
You can also refer to dose conversion for different animals. More
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INDY 1169755-45-6 Cell Cycle/Checkpoint Tyrosine Kinase/Adaptors DYRK 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one inhibitor inhibit