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INDY

Catalog No. T15579 CAS 1169755-45-6

INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.

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INDY, CAS 1169755-45-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
Targets&IC50	DYRK1B:0.23 μM, DYRK1A:(ki)0.18 μM, DYRK1A:0.24 μM
In vitro	INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM[1].
In vivo	In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently[1].

Molecular Weight	235.3
Formula	C12H13NO2S
CAS No.	1169755-45-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 5 mg/mL (21.25 mM), ultrasonic and warming and heat to 60°C

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ogawa Y, et al. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 2010 Oct 5;1:86. 2. Pozo N, et al. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastomagrowth. J Clin Invest. 2013 Jun;123(6):2475-87.

Related Products

Related compounds with same targets

LDN-192960 Protein kinase inhibitors 1 GNF2133 ML167 INDY EHT 1610 CLK-IN-T3 AZ-Dyrk1B-33

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

INDY 1169755-45-6 蛋白酪氨酸激酶细胞周期 DYRK Inhibitor inhibitor inhibit

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